Super-family SCOP ID

Number of proteins

Number of mutations

Descriptions

100895

1

2

Kazal-type serine protease inhibitors

100950

4

34

NagB/RpiA/CoA transferase-like

102114

1

5

Radical SAM enzymes

103145

1

4

Tombusvirus P19 core protein, VP19

109604

1

7

HD-domain/PDEase-like

110217

1

1

DNA-binding protein LAG-1 (CSL)

110738

1

4

Glycerate kinase I

111326

1

4

Urocanase

111418

1

4

Hormone receptor domain

117018

1

6

ATP-dependent DNA ligase DNA-binding domain

117023

1

2

DNA primase DnaG, C-terminal domain

161084

1

1

MAPEG domain-like

46458

2

3

Globin-like

46548

1

5

alpha-helical ferredoxin

46585

1

1

HR1 repeat

46600

1

10

C-terminal UvrC-binding domain of UvrB

46604

1

1

Epsilon subunit of F1F0-ATP synthase C-terminal domain

46609

2

6

Fe,Mn superoxide dismutase (SOD), N-terminal domain

46626

5

89

Cytochrome c

46689

2

24

Homeodomain-like

46767

2

13

Methylated DNA-protein cysteine methyltransferase, C-terminal domain

46785

5

17

Winged helix DNA-binding domain

46955

1

2

Putative DNA-binding domain

47027

1

11

Acyl-CoA binding protein

47077

1

1

T4 endonuclease V

47162

1

1

Apolipoprotein

47203

2

3

Acyl-CoA dehydrogenase C-terminal domain-like

47240

2

7

Ferritin-like

47266

12

236

4-helical cytokines

47353

1

109

Retrovirus capsid dimerization domain-like

47380

1

31

ROP protein

47413

3

779

lambda repressor-like DNA-binding domains

47473

11

45

EF-hand

47616

6

18

GST C-terminal domain-like

47648

1

1

Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain

47699

1

4

Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

47719

1

17

p53 tetramerization domain

47729

2

11

IHF-like DNA-binding proteins

47741

1

6

CO dehydrogenase ISP C-domain like

47757

1

1

Chemotaxis receptor methyltransferase CheR, N-terminal domain

47789

1

51

C-terminal domain of RNA polymerase alpha subunit

47802

1

1

DNA polymerase beta, N-terminal domain-like

47874

4

13

Annexin

47895

2

6

Transducin (alpha subunit), insertion domain

47917

1

5

C-terminal domain of alpha and beta subunits of F1 ATP synthase

47943

1

1

Retrovirus capsid protein, N-terminal core domain

47979

1

10

Iron-dependent repressor protein, dimerization domain

47986

2

9

DEATH domain

48034

2

2

Guanido kinase N-terminal domain

48097

2

12

Regulator of G-protein signaling, RGS

48113

6

73

Heme-dependent peroxidases

48150

2

11

DNA-glycosylase

48163

1

5

An anticodon-binding domain of class I aminoacyl-tRNA synthetases

48173

1

3

Cryptochrome/photolyase FAD-binding domain

48179

3

26

6-phosphogluconate dehydrogenase C-terminal domain-like

48201

1

2

Uteroglobin-like

48225

1

8

Seven-hairpin glycosidases

48230

2

27

Chondroitin AC/alginate lyase

48239

4

35

Terpenoid cyclases/Protein prenyltransferases

48256

4

21

Citrate synthase

48264

7

51

Cytochrome P450

48295

1

25

TrpR-like

48371

3

6

ARM repeat

48439

1

1

Protein prenylyltransferase

48445

1

1

14-3-3 protein

48484

4

14

Lipoxigenase

48508

8

53

Nuclear receptor ligand-binding domain

48537

3

19

Phospholipase C/P1 nuclease

48552

1

1

Serum albumin-like

48557

5

38

L-aspartase-like

48576

3

22

Terpenoid synthases

48600

2

4

Chorismate mutase II

48613

3

30

Heme oxygenase-like

48619

7

84

Phospholipase A2, PLA2

48726

18

143

Immunoglobulin

49265

4

40

Fibronectin type III

49309

1

4

Transglutaminase, two C-terminal domains

49329

4

29

Cu,Zn superoxide dismutase-like

49354

1

2

PapD-like

49401

1

1

Bacterial adhesins

49417

3

11

p53-like transcription factors

49452

1

1

Starch-binding domain-like

49472

1

10

Transthyretin (synonym: prealbumin)

49503

7

69

Cupredoxins

49562

1

1

C2 domain (Calcium/lipid-binding domain, CaLB)

49584

1

2

Periplasmic chaperone C-domain

49695

1

1

gamma-Crystallin-like

49723

2

10

Lipase/lipooxygenase domain (PLAT/LH2 domain)

49742

1

11

PHM/PNGase F

49785

3

16

Galactose-binding domain-like

49842

3

132

TNF-like

49879

1

1

SMAD/FHA domain

49899

10

70

Concanavalin A-like lectins/glucanases

49998

2

7

Amine oxidase catalytic domain

50022

1

9

ISP domain

50037

1

2

C-terminal domain of transcriptional repressors

50044

3

26

SH3-domain

50090

1

2

Electron transport accessory proteins

50129

3

12

GroES-like

50156

1

10

PDZ domain-like

50199

1

155

Staphylococcal nuclease

50203

1

7

Bacterial enterotoxins

50242

1

5

TIMP-like

50249

5

25

Nucleic acid-binding proteins

50324

3

19

Inorganic pyrophosphatase

50353

4

88

Cytokine

50370

1

2

Ricin B-like lectins

50475

1

9

FMN-binding split barrel

50486

2

22

FMT C-terminal domain-like

50494

25

337

Trypsin-like serine proteases

50610

1

2

mu transposase, C-terminal domain

50615

1

1

N-terminal domain of alpha and beta subunits of F1 ATP synthase

50621

2

10

Alanine racemase C-terminal domain-like

50630

9

187

Acid proteases

50685

1

6

Barwin-like endoglucanases

50729

5

25

PH domain-like

50789

1

1

Herpes virus serine proteinase, assemblin

50800

1

1

PK beta-barrel domain-like

50814

9

43

Lipocalins

50876

1

1

Avidin/streptavidin

50891

3

9

Cyclophilin-like

50911

1

7

Mannose 6-phosphate receptor domain

50923

1

11

Hemopexin-like domain

50939

2

27

Sialidases

50960

1

4

TolB, C-terminal domain

50965

1

2

Galactose oxidase, central domain

50974

1

20

Nitrous oxide reductase, N-terminal domain

50978

2

4

WD40 repeat-like

50993

1

1

Peptidase/esterase 'gauge' domain

51011

3

6

Glycosyl hydrolase domain

51045

1

3

WW domain

51069

5

98

Carbonic anhydrase

51120

1

3

beta-Roll

51126

4

43

Pectin lyase-like

51161

1

8

Trimeric LpxA-like enzymes

51182

7

45

RmlC-like cupins

51197

3

9

Clavaminate synthase-like

51206

1

3

cAMP-binding domain-like

51215

1

3

Regulatory protein AraC

51230

1

4

Single hybrid motif

51269

1

3

AFP III-like domain

51278

1

1

Urease, beta-subunit

51294

1

1

Hedgehog/intein (Hint) domain

51306

2

26

LexA/Signal peptidase

51344

1

11

Epsilon subunit of F1F0-ATP synthase N-terminal domain

51351

7

29

Triosephosphate isomerase (TIM)

51366

5

78

Ribulose-phoshate binding barrel

51395

5

17

FMN-linked oxidoreductases

51412

1

16

Inosine monophosphate dehydrogenase (IMPDH)

51419

1

4

PLP-binding barrel

51430

8

54

NAD(P)-linked oxidoreductase

51445

24

136

(Trans)glycosidases

51556

4

43

Metallo-dependent hydrolases

51569

7

39

Aldolase

51604

2

14

Enolase C-terminal domain-like

51621

5

23

Phosphoenolpyruvate/pyruvate domain

51649

1

1

RuBisCo, C-terminal domain

51658

7

45

Xylose isomerase-like

51679

2

13

Bacterial luciferase-like

51690

1

5

Nicotinate/Quinolinate PRTase C-terminal domain-like

51695

1

5

PLC-like phosphodiesterases

51703

1

18

Cobalamin (vitamin B12)-dependent enzymes

51726

1

5

UROD/MetE-like

51735

33

162

NAD(P)-binding Rossmann-fold domains

51905

12

62

FAD/NAD(P)-binding domain

51971

3

20

Nucleotide-binding domain

51989

1

12

Glycosyl hydrolases family 6, cellulases

51998

3

42

PFL-like glycyl radical enzymes

52009

1

2

Phosphohistidine domain

52016

1

1

LeuD/IlvD-like

52038

1

19

Barstar-related

52058

4

23

L domain-like

52096

1

5

ClpP/crotonase

52113

1

8

BRCT domain

52129

1

7

Caspase-like

52151

1

15

FabD/lysophospholipase-like

52210

1

2

Succinyl-CoA synthetase domains

52218

4

17

Flavoproteins

52242

1

9

Cobalamin (vitamin B12)-binding domain

52266

1

2

SGNH hydrolase

52283

4

7

Formate/glycerate dehydrogenase catalytic domain-like

52309

2

9

N-(deoxy)ribosyltransferase-like

52317

1

6

Class I glutamine amidotransferase-like

52335

1

5

Methylglyoxal synthase-like

52343

4

14

Ferredoxin reductase-like, C-terminal NADP-linked domain

52374

13

57

Nucleotidylyl transferase

52418

2

8

Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

52425

1

2

Cryptochrome/photolyase, N-terminal domain

52440

3

9

PreATP-grasp domain

52467

2

14

DHS-like NAD/FAD-binding domain

52518

6

32

Thiamin diphosphate-binding fold (THDP-binding)

52540

52

435

P-loop containing nucleoside triphosphate hydrolases

52743

5

104

Subtilisin-like

52768

2

9

Arginase/deacetylase

52777

2

31

CoA-dependent acyltransferases

52788

1

25

Phosphotyrosine protein phosphatases I

52799

4

26

(Phosphotyrosine protein) phosphatases II

52821

2

22

Rhodanese/Cell cycle control phosphatase

52833

11

46

Thioredoxin-like

52935

3

3

PK C-terminal domain-like

52943

1

12

ATP synthase (F1-ATPase), gamma subunit

52980

1

10

Restriction endonuclease-like

53041

1

6

Resolvase-like

53062

1

3

PTS system fructose IIA component-like

53067

8

75

Actin-like ATPase domain

53092

1

1

Creatinase/prolidase N-terminal domain

53098

7

102

Ribonuclease H-like

53155

1

10

Methylated DNA-protein cysteine methyltransferase domain

53167

2

9

Purine and uridine phosphorylases

53178

1

13

Peptidyl-tRNA hydrolase-like

53187

5

20

Zn-dependent exopeptidases

53223

2

7

Aminoacid dehydrogenase-like, N-terminal domain

53244

1

1

MurD-like peptide ligases, peptide-binding domain

53254

7

29

Phosphoglycerate mutase-like

53271

7

33

PRTase-like

53300

4

46

vWA-like

53328

2

32

Formyltransferase

53335

12

79

S-adenosyl-L-methionine-dependent methyltransferases

53383

17

151

PLP-dependent transferases

53448

6

39

Nucleotide-diphospho-sugar transferases

53474

24

166

alpha/beta-Hydrolases

53597

3

49

Dihydrofolate reductase-like

53613

3

15

Ribokinase-like

53623

1

3

MurD-like peptide ligases, catalytic domain

53639

1

2

AraD/HMP-PK domain-like

53649

5

74

Alkaline phosphatase-like

53659

6

41

Isocitrate/Isopropylmalate dehydrogenase-like

53671

4

19

Aspartate/ornithine carbamoyltransferase

53681

1

1

Aspartate/glutamate racemase

53686

3

27

Tryptophan synthase beta subunit-like PLP-dependent enzymes

53706

1

1

Formate dehydrogenase/DMSO reductase, domains 1-3

53720

2

17

ALDH-like

53732

3

3

Aconitase iron-sulfur domain

53748

2

35

Phosphoglycerate kinase

53756

6

29

UDP-Glycosyltransferase/glycogen phosphorylase

53774

3

26

Glutaminase/Asparaginase

53784

2

26

Phosphofructokinase

53800

3

18

Chelatase

53807

2

21

Helical backbone metal receptor

53822

2

2

Periplasmic binding protein-like I

53850

3

29

Periplasmic binding protein-like II

53901

2

13

Thiolase-like

53927

3

12

Cytidine deaminase-like

53933

4

89

Microbial ribonucleases

53955

7

221

Lysozyme-like

54001

11

56

Cysteine proteinases

54060

3

19

His-Me finger endonucleases

54076

2

49

RNase A-like

54098

1

1

Prion-like

54117

4

20

Interleukin 8-like chemokines

54197

2

20

HIT-like

54211

3

24

Ribosomal protein S5 domain 2-like

54236

3

34

Ubiquitin-like

54292

8

38

2Fe-2S ferredoxin-like

54334

1

1

Superantigen toxins, C-terminal domain

54358

1

18

Immunoglobulin-binding domains

54373

7

15

FAD-linked reductases, C-terminal domain

54403

2

6

Cystatin/monellin

54416

1

1

Amine oxidase N-terminal region

54427

4

23

NTF2-like

54452

9

91

MHC antigen-recognition domain

54495

1

2

UBC-like

54534

2

59

FKBP-like

54593

4

21

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

54611

1

2

SecB-like

54626

1

14

Chalcone isomerase

54637

1

4

Thioesterase/thiol ester dehydrase-isomerase

54654

2

13

CI-2 family of serine protease inhibitors

54665

1

2

CO dehydrogenase molybdoprotein N-domain-like

54675

1

2

Nicotinate/Quinolinate PRTase N-terminal domain-like

54680

1

2

Pyrimidine nucleoside phosphorylase C-terminal domain

54695

2

26

POZ domain

54719

2

4

Fe,Mn superoxide dismutase (SOD), C-terminal domain

54782

1

1

Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain

54826

1

2

Enolase N-terminal domain-like

54893

1

1

Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain

54919

5

65

Nucleoside diphosphate kinase, NDK

54928

3

14

RNA-binding domain, RBD

54957

1

3

Viral DNA-binding domain

54975

1

4

Acylphosphatase/BLUF domain-like

55003

1

2

PAP/Archaeal CCA-adding enzyme, C-terminal domain

55021

3

23

ACT-like

55060

1

5

GHMP Kinase, C-terminal domain

55068

2

3

Peptide methionine sulfoxide reductase

55073

4

24

Nucleotide cyclase

55083

1

2

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK

55103

1

2

FAD-linked oxidases, C-terminal domain

55120

1

3

Pseudouridine synthase

55190

1

3

Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain

55205

3

12

EPT/RTPC-like

55234

1

5

Cyanase C-terminal domain

55271

1

1

DNA repair protein MutS, domain I

55298

1

4

YjgF-like

55326

1

6

PurM N-terminal domain-like

55331

2

3

Tautomerase/MIF

55347

7

28

Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain

55394

1

3

Bactericidal permeability-increasing protein, BPI

55399

1

13

Subtilisin inhibitor

55418

1

2

eIF4e-like

55424

4

10

FAD/NAD-linked reductases, dimerisation (C-terminal) domain

55447

1

2

CO dehydrogenase flavoprotein C-terminal domain-like

55455

1

12

SRF-like

55469

1

3

FMN-dependent nitroreductase-like

55486

24

201

Metalloproteases ("zincins"), catalytic domain

55550

2

29

SH2 domain

55594

2

55

HPr-like

55604

1

1

Glucose permease domain IIB

55608

1

6

Homing endonucleases

55620

3

7

Tetrahydrobiopterin biosynthesis enzymes-like

55637

1

6

Cell cycle regulatory proteins

55671

1

4

Regulatory factor Nef

55681

3

23

Class II aaRS and biotin synthetases

55718

2

7

SCP-like

55729

2

15

Acyl-CoA N-acyltransferases (Nat)

55753

2

20

Actin depolymerizing proteins

55770

2

7

Profilin (actin-binding protein)

55785

1

12

PYP-like sensor domain (PAS domain)

55811

2

5

Nudix

55831

4

157

Thymidylate synthase/dCMP hydroxymethylase

55846

1

11

N-acetylmuramoyl-L-alanine amidase-like

55856

2

3

Cytochrome b5-like heme/steroid binding domain

55874

4

10

ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase

55895

2

23

Ribonuclease Rh-like

55909

1

14

Pentein

55920

4

16

Creatinase/aminopeptidase

55931

3

15

Glutamine synthetase/guanido kinase

55945

2

34

TATA-box binding protein-like

55961

1

14

Bet v1-like

55973

4

30

S-adenosylmethionine synthetase

55979

2

2

DNA clamp

56003

1

12

Molybdenum cofactor-binding domain

56014

1

2

Nitrite and sulphite reductase 4Fe-4S domain-like

56059

7

39

Glutathione synthetase ATP-binding domain-like

56091

1

5

DNA ligase/mRNA capping enzyme, catalytic domain

56112

26

227

Protein kinase-like (PK-like)

56176

3

9

FAD-binding/transporter-associated domain-like

56219

4

72

DNase I-like

56235

8

53

N-terminal nucleophile aminohydrolases (Ntn hydrolases)

56276

2

16

S-adenosylmethionine decarboxylase

56300

3

27

Metallo-dependent phosphatases

56317

1

8

Carbon-nitrogen hydrolase

56322

1

6

ADC synthase

56327

5

32

LDH C-terminal domain-like

56349

1

2

DNA breaking-rejoining enzymes

56366

1

3

SMAD MH1 domain

56371

7

30

Ribosome inactivating proteins (RIP)

56399

1

4

ADP-ribosylation

56420

1

53

Peptide deformylase

56425

1

2

Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

56436

5

87

C-type lectin-like

56507

1

22

Methionine synthase activation domain-like

56512

4

39

Nitric oxide (NO) synthase oxygenase domain

56524

1

4

Oxidoreductase molybdopterin-binding domain

56534

5

51

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains

56548

1

4

Conserved core of transcriptional regulatory protein vp16

56574

4

63

Serpins

56596

1

1

Replication terminator protein (Tus)

56601

10

76

beta-lactamase/transpeptidase-like

56634

1

3

Heme-dependent catalase-like

56645

3

10

Acyl-CoA dehydrogenase NM domain-like

56655

6

45

Carbohydrate phosphatase

56672

8

607

DNA/RNA polymerases

56712

1

12

Prokaryotic type I DNA topoisomerase

56719

2

7

Type II DNA topoisomerase

56752

2

13

D-aminoacid aminotransferase-like PLP-dependent enzymes

56784

3

70

HAD-like

56925

1

7

OMPA-like

56931

1

15

Outer membrane phospholipase A (OMPLA)

56935

5

60

Porins

56973

1

10

Aerolisin/ETX pore-forming domain

56983

1

4

Viral glycoprotein, central and dimerisation domains

56994

2

12

Insulin-like

57184

1

19

Growth factor receptor domain

57196

1

22

EGF/Laminin

57247

1

4

Bowman-Birk inhibitor, BBI

57262

1

15

Leech antihemostatic proteins

57302

4

44

Snake toxin-like

57362

1

33

BPTI-like

57424

1

3

LDL receptor-like module

57440

1

14

Kringle-like

57501

5

75

Cystine-knot cytokines

57535

2

14

Complement control module/SCR domain

57581

1

6

TB module/8-cys domain

57610

1

3

Thyroglobulin type-1 domain

57716

4

45

Glucocorticoid receptor-like (DNA-binding domain)

57774

2

6

Microbial and mitochondrial ADK, insert "zinc finger" domain

57783

2

17

Zinc beta-ribbon

57798

1

4

Casein kinase II beta subunit

57825

1

9

Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain

57850

1

1

RING/U-box

57889

1

27

Cysteine-rich domain

57924

2

6

Inhibitor of apoptosis (IAP) repeat

57959

3

35

Leucine zipper domain

58038

1

1

SNARE fusion complex

58042

1

8

Outer membrane lipoprotein

58064

1

4

Influenza hemagglutinin (stalk)

58069

2

39

Virus ectodomain

58104

1

10

Methyl-accepting chemotaxis protein (MCP) signaling domain

58113

1

3

Apolipoprotein A-I

58181

1

4

RNA polymerase

58379

1

25

Parathyroid hormone fragments (residues between 1 and 39)

63380

8

31

Riboflavin synthase domain-like

63411

2

22

LuxS/MPP-like metallohydrolase

63592

1

41

Flagellar transcriptional activator FlhD

63748

1

6

Tudor/PWWP/MBT

63829

1

15

Calcium-dependent phosphotriesterase

64005

1

3

Undecaprenyl diphosphate synthase

64158

1

2

2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain

64484

1

3

beta and beta-prime subunits of DNA dependent RNA-polymerase

69012

1

5

alpha-ketoacid dehydrogenase kinase, N-terminal domain

69189

1

1

Penicillin-binding protein associated domain

69318

1

7

Integrin alpha N-terminal domain

69687

1

1

Integrin beta tail domain

69695

1

3

SRP19

69765

1

2

IpsF-like

74650

2

2

Galactose mutarotase-like

74800

1

1

Transactivation domain

74863

1

2

Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)

75001

1

2

Dipeptidyl peptidase I (cathepsin C), exclusion domain

75005

1

1

Arabinanase/levansucrase/invertase

75620

1

1

Release factor

81296

2

5

E set domains

81301

3

28

Nucleotidyltransferase

81321

3

160

Family A G protein-coupled receptor-like

81324

1

6

Voltage-gated potassium channels

81342

1

36

Transmembrane di-heme cytochromes

81343

3

19

Fumarate reductase respiratory complex transmembrane subunits

81442

2

24

Cytochrome c oxidase subunit I-like

81483

1

4

Bacterial photosystem II reaction centre, L and M subunits

81573

1

13

F1F0 ATP synthase subunit B, membrane domain

81593

1

3

Nucleotidyltransferase substrate binding subunit/domain

81631

1

2

PAP/OAS1 substrate-binding domain

81648

1

4

a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)

81653

1

11

Calcium ATPase, transduction domain A

81660

1

7

Metal cation-transporting ATPase, ATP-binding domain N

81665

1

74

Calcium ATPase, transmembrane domain M

81923

1

2

Double Clp-N motif

82114

1

3

Riboflavin kinase-like

82199

1

2

SET domain

82282

1

7

Homocysteine S-methyltransferase

88648

2

2

Group I dsDNA viruses

88659

1

24

Sigma3 and sigma4 domains of RNA polymerase sigma factors

88713

2

13

Glycoside hydrolase/deacetylase

88946

1

6

Sigma2 domain of RNA polymerase sigma factors

89392

1

1

Prokaryotic lipoproteins and lipoprotein localization factors

89550

1

2

PHP domain-like

90073

1

25

GCM domain

90188

1

6

Somatomedin B domain