Fold SCOP ID

Number of proteins

Number of mutations

Descriptions

100877

1

3

Pseudouridine synthase

100894

1

2

Kazal-type serine protease inhibitors

100949

4

34

NagB/RpiA/CoA transferase-like

103144

1

4

Tombusvirus P19 core protein, VP19

109603

1

7

HD-domain/PDEase-like

110737

1

4

Glycerate kinase I

111325

1

4

Urocanase

111417

1

4

Hormone receptor domain

117017

1

6

ATP-dependent DNA ligase DNA-binding domain

117022

1

2

DNA primase DnaG, C-terminal domain

161083

1

1

MAPEG domain-like

46457

3

8

Globin-like

46556

5

18

Long alpha-hairpin

46625

5

89

Cytochrome c

46688

11

103

DNA/RNA-binding 3-helical bundle

46954

1

2

Putative DNA-binding domain

47026

1

11

Acyl-CoA binding protein-like

47076

1

1

T4 endonuclease V

47161

2

4

Four-helical up-and-down bundle

47239

2

7

Ferritin-like

47265

12

236

4-helical cytokines

47335

1

109

Acyl carrier protein-like

47363

3

8

Bromodomain-like

47379

1

31

ROP-like

47412

3

779

lambda repressor-like DNA-binding domains

47472

11

45

EF Hand-like

47615

6

18

GST C-terminal domain-like

47643

1

1

Methionine synthase domain-like

47698

1

4

Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

47718

1

17

p53 tetramerization domain

47728

2

11

IHF-like DNA-binding proteins

47740

1

6

CO dehydrogenase ISP C-domain like

47756

1

1

Chemotaxis receptor methyltransferase CheR, N-terminal domain

47768

2

52

SAM domain-like

47873

4

13

Annexin

47894

2

6

Transducin (alpha subunit), insertion domain

47916

1

5

Left-handed superhelix

47942

1

1

Retrovirus capsid protein, N-terminal core domain

47978

1

10

Iron-dependent repressor protein, dimerization domain

47985

2

9

DEATH domain

48033

2

2

Guanido kinase N-terminal domain

48096

2

12

Regulator of G-protein signaling, RGS

48112

6

73

Heme-dependent peroxidases

48149

2

11

DNA-glycosylase

48162

1

5

An anticodon-binding domain of class I aminoacyl-tRNA synthetases

48172

1

3

Cryptochrome/photolyase FAD-binding domain

48178

3

26

6-phosphogluconate dehydrogenase C-terminal domain-like

48200

1

2

Uteroglobin-like

48207

7

70

alpha/alpha toroid

48255

4

21

Citrate synthase

48263

7

51

Cytochrome P450

48370

5

8

alpha-alpha superhelix

48483

4

14

Lipoxigenase

48507

8

53

Nuclear receptor ligand-binding domain

48536

3

19

Phospholipase C/P1 nuclease

48551

1

1

Serum albumin-like

48556

5

38

L-aspartase-like

48575

3

22

Terpenoid synthases

48599

2

4

Chorismate mutase II

48612

3

30

Heme oxygenase-like

48618

7

84

Phospholipase A2, PLA2

48725

30

225

Immunoglobulin-like beta-sandwich

49379

4

12

Common fold of diphtheria toxin/transcription factors/cytochrome f

49451

2

11

Prealbumin-like

49502

7

69

Cupredoxin-like

49561

2

3

C2 domain-like

49694

1

1

gamma-Crystallin-like

49722

2

10

Lipase/lipooxygenase domain (PLAT/LH2 domain)

49784

3

16

Galactose-binding domain-like

49841

3

132

TNF-like

49878

1

1

SMAD/FHA domain

49898

10

70

Concanavalin A-like lectins/glucanases

49993

4

9

Supersandwich

50021

1

9

ISP domain

50036

6

36

SH3-like barrel

50128

3

12

GroES-like

50155

1

10

PDZ domain-like

50198

11

211

OB-fold

50352

6

91

beta-Trefoil

50412

9

34

Reductase/isomerase/elongation factor common domain

50474

1

9

Split barrel-like

50485

2

22

FMT C-terminal domain-like

50493

25

337

Trypsin-like serine proteases

50609

1

2

mu transposase, C-terminal domain

50614

3

11

Domain of alpha and beta subunits of F1 ATP synthase-like

50629

9

187

Acid proteases

50684

1

6

Double psi beta-barrel

50728

5

25

PH domain-like barrel

50788

1

1

Herpes virus serine proteinase, assemblin

50799

1

1

PK beta-barrel domain-like

50813

9

43

Lipocalins

50875

2

3

Streptavidin-like

50890

3

9

Cyclophilin-like

50910

1

7

Mannose 6-phosphate receptor domain

50922

1

11

4-bladed beta-propeller

50933

1

1

5-bladed beta-propeller

50938

4

46

6-bladed beta-propeller

50964

6

34

7-bladed beta-propeller

51010

3

6

Glycosyl hydrolase domain

51044

1

3

WW domain-like

51068

5

98

Carbonic anhydrase

51125

5

46

Single-stranded right-handed beta-helix

51160

1

8

Single-stranded left-handed beta-helix

51181

13

71

Double-stranded beta-helix

51229

1

4

Barrel-sandwich hybrid

51268

3

6

beta-clip

51293

1

1

Hedgehog/intein (Hint) domain

51305

2

26

LexA/Signal peptidase

51343

1

11

Epsilon subunit of F1F0-ATP synthase N-terminal domain

51350

85

557

TIM beta/alpha-barrel

51734

33

162

NAD(P)-binding Rossmann-fold domains

51904

12

62

FAD/NAD(P)-binding domain

51970

3

20

Nucleotide-binding domain

51988

4

27

7-stranded beta/alpha barrel

51997

3

42

PFL-like glycyl radical enzymes

52008

2

3

The "swivelling" beta/beta/alpha domain

52037

1

19

Barstar-like

52046

4

23

Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)

52095

1

5

ClpP/crotonase

52112

1

8

BRCT domain

52128

1

7

Caspase-like

52150

1

15

FabD/lysophospholipase-like

52171

14

52

Flavodoxin-like

52334

1

5

Methylglyoxal synthase-like

52342

4

14

Ferredoxin reductase-like, C-terminal NADP-linked domain

52373

13

57

Adenine nucleotide alpha hydrolase-like

52417

2

8

Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

52424

1

2

Cryptochrome/photolyase, N-terminal domain

52439

3

9

PreATP-grasp domain

52466

2

14

DHS-like NAD/FAD-binding domain

52517

6

32

Thiamin diphosphate-binding fold (THDP-binding)

52539

52

435

P-loop containing nucleoside triphosphate hydrolases

52742

5

104

Subtilisin-like

52767

2

9

Arginase/deacetylase

52776

2

31

CoA-dependent acyltransferases

52787

1

25

Phosphotyrosine protein phosphatases I-like

52798

4

26

(Phosphotyrosine protein) phosphatases II

52820

2

22

Rhodanese/Cell cycle control phosphatase

52832

11

46

Thioredoxin fold

52934

4

15

Pyruvate kinase C-terminal domain-like

52979

1

10

Restriction endonuclease-like

53040

1

6

Resolvase-like

53061

1

3

PTS system fructose IIA component-like

53066

17

188

Ribonuclease H-like motif

53162

8

42

Phosphorylase/hydrolase-like

53222

2

7

Aminoacid dehydrogenase-like, N-terminal domain

53243

1

1

MurD-like peptide ligases, peptide-binding domain

53253

7

29

Phosphoglycerate mutase-like

53270

7

33

PRTase-like

53299

4

46

vWA-like

53327

2

32

Formyltransferase

53334

12

79

S-adenosyl-L-methionine-dependent methyltransferases

53382

17

151

PLP-dependent transferase-like

53447

6

39

Nucleotide-diphospho-sugar transferases

53473

24

166

alpha/beta-Hydrolases

53596

3

49

Dihydrofolate reductase-like

53612

4

18

Ribokinase-like

53638

1

2

AraD/HMP-PK domain-like

53648

5

74

Alkaline phosphatase-like

53658

6

41

Isocitrate/Isopropylmalate dehydrogenase-like

53670

5

20

ATC-like

53685

3

27

Tryptophan synthase beta subunit-like PLP-dependent enzymes

53705

1

1

Formate dehydrogenase/DMSO reductase, domains 1-3

53719

2

17

ALDH-like

53731

3

3

Aconitase iron-sulfur domain

53747

2

35

Phosphoglycerate kinase

53755

6

29

UDP-Glycosyltransferase/glycogen phosphorylase

53773

3

26

Glutaminase/Asparaginase

53783

2

26

Phosphofructokinase

53799

5

39

Chelatase-like

53821

2

2

Periplasmic binding protein-like I

53849

3

29

Periplasmic binding protein-like II

53900

2

13

Thiolase-like

53926

3

12

Cytidine deaminase-like

53932

4

89

Microbial ribonucleases

53954

7

221

Lysozyme-like

54000

11

56

Cysteine proteinases

54059

3

19

His-Me finger endonucleases

54075

2

49

RNase A-like

54097

1

1

Prion-like

54116

4

20

IL8-like

54196

2

20

HIT-like

54210

3

24

Ribosomal protein S5 domain 2-like

54235

13

91

beta-Grasp (ubiquitin-like)

54372

7

15

FAD-linked reductases, C-terminal domain

54402

7

30

Cystatin-like

54451

9

91

MHC antigen-recognition domain

54494

1

2

UBC-like

54533

2

59

FKBP-like

54592

4

21

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

54610

1

2

SecB-like

54625

1

14

Chalcone isomerase

54636

1

4

Thioesterase/thiol ester dehydrase-isomerase

54653

2

13

CI-2 family of serine protease inhibitors

54664

3

6

alpha/beta-Hammerhead

54694

2

26

POZ domain

54718

2

4

Fe,Mn superoxide dismutase (SOD), C-terminal domain

54767

1

1

dsRBD-like

54825

1

2

Enolase N-terminal domain-like

54861

24

148

Ferredoxin-like

55185

1

3

RRF/tRNA synthetase additional domain-like

55199

3

12

IF3-like

55233

1

5

Cyanase C-terminal domain

55266

1

1

MutS N-terminal domain-like

55297

3

12

Bacillus chorismate mutase-like

55330

2

3

Tautomerase/MIF

55346

7

28

FwdE/GAPDH domain-like

55393

1

3

Aha1/BPI domain-like

55398

1

13

Subtilisin inhibitor

55417

1

2

eIF4e-like

55423

5

12

CO dehydrogenase flavoprotein C-domain-like

55454

1

12

SRF-like

55468

1

3

FMN-dependent nitroreductase-like

55485

24

201

Zincin-like

55549

2

29

SH2-like

55593

2

55

HPr-like

55603

2

7

Homing endonuclease-like

55619

3

7

T-fold

55636

1

6

Cell cycle regulatory proteins

55670

1

4

Regulatory factor Nef

55680

3

23

Class II aaRS and biotin synthetases

55717

2

7

SCP-like

55728

2

15

Acyl-CoA N-acyltransferases (Nat)

55752

2

20

Gelsolin-like

55769

3

19

Profilin-like

55810

2

5

Nudix

55830

4

157

Thymidylate synthase/dCMP hydroxymethylase

55845

1

11

N-acetylmuramoyl-L-alanine amidase-like

55855

2

3

Cytochrome b5-like heme/steroid binding domain

55873

4

10

ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase

55894

2

23

Ribonuclease Rh-like

55908

1

14

Pentein, beta/alpha-propeller

55919

4

16

Creatinase/aminopeptidase

55930

3

15

Glutamine synthetase/guanido kinase

55944

3

48

TBP-like

55972

4

30

S-adenosylmethionine synthetase

55978

2

2

DNA clamp

56002

1

12

Molybdenum cofactor-binding domain

56058

1

5

ATP-grasp

56111

26

227

Protein kinase-like (PK-like)

56175

3

9

FAD-binding/transporter-associated domain-like

56218

4

72

DNase I-like

56234

8

53

Ntn hydrolase-like

56275

2

16

S-adenosylmethionine decarboxylase

56299

3

27

Metallo-dependent phosphatases

56316

1

8

Carbon-nitrogen hydrolase

56321

1

6

ADC synthase

56326

5

32

LDH C-terminal domain-like

56348

1

2

DNA breaking-rejoining enzymes

56365

1

3

SMAD MH1 domain

56370

7

30

Ribosome inactivating proteins (RIP)

56398

1

4

ADP-ribosylation

56419

1

53

Peptide deformylase

56424

1

2

Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

56435

5

87

C-type lectin-like

56506

1

22

Methionine synthase activation domain-like

56511

4

39

Nitric oxide (NO) synthase oxygenase domain

56523

1

4

Oxidoreductase molybdopterin-binding domain

56533

5

51

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains

56547

1

4

Conserved core of transcriptional regulatory protein vp16

56573

4

63

Serpins

56595

1

1

Replication terminator protein (Tus)

56600

10

76

beta-lactamase/transpeptidase-like

56633

1

3

Heme-dependent catalase-like

56644

3

10

Acyl-CoA dehydrogenase NM domain-like

56654

6

45

Carbohydrate phosphatase

56671

8

607

DNA/RNA polymerases

56711

1

12

Prokaryotic type I DNA topoisomerase

56718

2

7

Type II DNA topoisomerase

56751

2

13

D-aminoacid aminotransferase-like PLP-dependent enzymes

56783

3

70

HAD-like

56924

7

82

Transmembrane beta-barrels

56972

1

10

Aerolisin/ETX pore-forming domain

56982

1

4

Viral glycoprotein, central and dimerisation domains

56993

2

12

Insulin-like

57015

4

60

Knottins (small inhibitors, toxins, lectins)

57301

4

44

Snake toxin-like

57361

1

33

BPTI-like

57423

1

3

LDL receptor-like module

57439

1

14

Kringle-like

57500

5

75

Cystine-knot cytokines

57534

2

14

Complement control module/SCR domain

57580

1

6

TB module/8-cys domain

57609

1

3

Thyroglobulin type-1 domain

57715

4

45

Glucocorticoid receptor-like (DNA-binding domain)

57769

6

36

Rubredoxin-like

57849

1

1

RING/U-box

57888

1

27

Cysteine-rich domain

57923

2

6

Inhibitor of apoptosis (IAP) repeat

57943

5

44

Parallel coiled-coil

58063

3

43

Stalk segment of viral fusion proteins

58086

1

10

Antiparallel coiled-coil

58112

1

3

Apolipoprotein A-I

58180

1

4

RNA polymerase

58378

1

25

Parathyroid hormone fragments (residues between 1 and 39)

63410

2

22

LuxS/MPP-like metallohydrolase

63591

1

41

Flagellar transcriptional activator FlhD

64004

1

3

Undecaprenyl diphosphate synthase

64157

1

2

2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain

64483

1

3

beta and beta-prime subunits of DNA dependent RNA-polymerase

69188

1

1

Penicillin-binding protein associated domain

69686

1

1

Integrin beta tail domain

69694

1

3

SRP19

75619

1

1

Release factor

81275

1

1

Transactivation domain

81302

3

28

Nucleotidyltransferase

81322

3

160

Family A G protein-coupled receptor-like

81325

1

6

Voltage-gated potassium channels

81344

4

55

Heme-binding four-helical bundle

81407

1

13

Single transmembrane helix

81443

2

24

Cytochrome c oxidase subunit I-like

81484

1

4

Bacterial photosystem II reaction centre, L and M subunits

81632

1

2

PAP/OAS1 substrate-binding domain

81649

1

4

a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)

81661

1

7

Metal cation-transporting ATPase, ATP-binding domain N

81666

1

74

Calcium ATPase, transmembrane domain M

81922

1

2

Double Clp-N motif

88632

3

13

Nucleoplasmin-like/VP (viral coat and capsid proteins)

88945

1

6

Sigma2 domain of RNA polymerase sigma factors

89391

1

1

LolA-like prokaryotic lipoproteins and lipoprotein localization factors

90072

1

25

GCM domain

90187

1

6

Somatomedin B domain